Current Issue : October - December Volume : 2020 Issue Number : 4 Articles : 8 Articles
The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell\nadhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the\nrelationships between CEACAM1 and GDM.\nMethods: Circulating CEACAM1 levels were measured by ELISA kit in 70 women with GDM and 70 normal glucose\ntolerance (NGT) pregnant women. Blood samples were collected to detect fasting plasma glucose (FPG), fasting\ninsulin (FINS) and glycosylated hemoglobin (HbA1c) levels in all participants. Insulin sensitivity index (ISOGTT) was\ncalculated to assess insulin sensitivity. Correlation analysis was performed between serum CEACAM1 levels and\nother parameters.\nResults: Circulating CEACAM1 levels were higher in the GDM group than that in the NGT pregnant group, however,\nthe difference showed no statistical significance.................
Hereditary medullary thyroid carcinoma (MTC) is mainly caused by germline mutations in the RET\nproto-oncogene, which accounts for 20â??30% of all MTC according to foreign studies. However, no English\nliteratures have reported Chinese hereditary MTC. Here, we reported two Chinese brothers with MTC that caused by\ngermline RET mutation.\nCase presentation: The younger brother was diagnosed with MTC at 29 years ago and suffered recurrence more\nthan 10 years. For elder brother, the diagnosis of MTC was made by postoperative pathological examination at age\n61. Both patients received total thyroidectomy and lymph node dissection. Since they had a significant family\nhistory for MTC, genetic detection was performed and identified a germline mutation in RET exon 10 (p.C620Y). This\nmutation was also detected in their offspring, indicating a moderate risk of MTC.\nConclusions: This is the first report presenting a Chinese family with hereditary MTC caused by the RET p.C620Y\nvariant. This case series emphasize the importance of genetic detection of RET proto-oncogene for MTC patients,\nand bring out managements for individuals after detection of RET mutations....
Acute compartment syndrome is a rare complication of severe hypothyroidism. If the symptoms are\nnot recognized promptly and treatment initiated immediately, there is a high risk of permanent damage. Only few\nother cases of compartment syndrome due to hypothyroidism have been published and the exact\npathophysiological mechanism remains unknown.\nCase presentations: A 59 year old male developed acute compartment syndrome of his right lower leg after\nthyroid hormone withdrawal prior to radioiodine remnant ablation after total thyroidectomy for follicular thyroid\ncancer. He underwent emergency fasciotomy of all four compartments of the lower leg. The muscle tissue in the\nanterior and lateral compartment was necrotic and was therefore excised. The second patient was a 62 year old\nfemale with Hashimotoâ??s thyroiditis, who developed acute compartment syndrome of both lower legs after thyroid\nhormone withdrawal due to non-compliance. Emergency fasciotomy of all four compartments of both legs was\nperformed. The muscle tissue was viable in all compartments.\nConclusion: Although compartment syndrome due to hypothyroidism is uncommon, it is a complication\nphysicians should be aware of. The majority of reported cases are caused by an acute withdrawal of thyroid\nhormones and not by undetected hypothyroidism. No previous case of compartment syndrome caused by an\niatrogenic hormone withdrawal in preparation for radioactive iodine has been published. However, as shown in this\nreport, it may be beneficial to inform patients of this rare complication prior to hormone withdrawal in preparation\nfor remnant ablation after thyroidectomy....
Glucocorticoid (GC)-induced hyperglycemia is characterized by elevated postprandial blood glucose,\nwhich commonly requires multiple insulin injections. We investigated whether a long-acting glucagon-like peptide-\n1 receptor agonist, dulaglutide (Dula), safely improved GC-induced hyperglycemia in inpatients, to reduce insulin\ninjection frequency.\nMethods: The data of hospitalized patients with GC-induced hyperglycemia treated with Dula (Dula group, n = 38)\nor without (non-Dula group, n = 38) were retrospectively evaluated. Baseline data were collected at the beginning\nof GC treatment. The primary outcome in this study was glycemic control, which was compared between the\ngroups using the six-point blood glucose (before and 2 h after each meal) profiles at discharge. The daily injection\nfrequency of injectable drugs at discharge were also compared between groups...............
Aging is associated with an anatomical and functional heterogeneity\nof the thyroid which varies according to the iodized status. The aim\nwas to describe the clinical, etiology and therapeutic profile of dysthyroidism\nin elderly subjects in the internal medicine at the Abass Ndao University\nHospital. Patients and methods: This was a retrospective, descriptive and\nanalytical study, including all subjects aged 60 and over followed from January\n1, 2010 to December 31, 2019 (10 years) for thyroid disease. Results: 371\nPatients were collected with a prevalence of 3.8%. The sex ratio was 0.15 and\nthe mean age was 65.3 years. The circumstances of discovery of the disease\nwere a grade 2 - 3 goiter (62.5%), exophthalmos (24.5%), thyrotoxicosis (56.6%),\na symptom of low metabolism (5.4%), a cervical compression (10.8% including\n8% of dysphasia), and a cardiothyreosis (9.4%). It was hyperthyroidism\n(65.2%), and hypothyroidism (7.2%). The main etiologies were toxic multinodular\ngoiter (33.2%), Gravesâ??s disease (29.6%), euthyroidism nodular goiter\n(26.8%), toxic adenoma (2.4%), and Hashimotoâ??s thyroiditis (6.7%). The\ncompressive manifestations were exclusive of nodular goiter. Among the 35\ncases of cardiothyreosis, there was a rhythm and conduction disorder in 25\ncases (6.7%) and the underlying thyreopathy was a toxic nodular goiter in\n57.1%. Thyroidectomy involved 44.7% of patients, including 32.6% of Gravesâ??\ndisease, 48.3% of toxic nodular goiter, and 61.8% of nodular goiter in euthyroidism.\nWe found 02 cases of papillary carcinomas on multinodular goiter.\nConclusion: In our hospital series, there is variability in the clinical manifestations\nof dysthyroidism in the elderly. Complications, mainly cardiac and\ncompressive, remain a major reason for consultation. Toxic nodular goiter is\npreponderant and its management, especially radical, must be multidisciplinary\nand according to the profile....
Cardiac damage triggered by severe hypocalcemia is well known. However, the role of chronic\nhypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) in cardiac health is still unclear. We investigated the\neffect of chronic HP and PHP on cardiac structure and conductive function in patients compiling with treatment.................
Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It\nhas been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM).\nHowever, previous reports were inconsistent.\nMethods: Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the\nRotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or\nNonparametric test was used to detect differences between PCOS and control groups. Spearmanâ??s correlation\nanalysis was used to examine the association of the serum Fetuin-A with other parameters..........
Thyroid hormone has been shown to be involved in carcinogenesis via its effects on cell proliferation\npathways. The objective of this study is to determine the association between subclinical hypothyroidism (SCH) and\nthe risk of incident cancer and cancer mortality via systematic review.\nMethods: A systematic search was performed on Medline and Pubmed to identify relevant studies. Randomized\ncontrolled trials, and observational studies assessing SCH or its treatment and the risk of incident cancer or cancer\nmortality were identified.\nResults: A total of 7 cohort and 2 case-control studies met our inclusion criteria. In general, these studies were of\nmedium to good quality. Overall, studies revealed no association between SCH and breast and prostate cancer...................
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